Summary:
- This study investigates the molecular mechanisms by which the *Salmonella* effector protein SseK1 inhibits the host's NF-κB signaling pathway by targeting the TAB2/TAB3 proteins for arginine GlcNAcylation.
- The research elucidates how this specific post-translational modification disrupts the formation of the TAK1 signaling complex, thereby dampening the host's innate immune response to bacterial infection.