Summary:
- This preprint investigates the role of the mitochondrial protein SLC25A39 in the regulation of mitochondrial glutathione (mtGSH) levels, which are critical for maintaining cellular redox homeostasis.
- The authors utilize CRISPR-Cas9 knockout models and biochemical assays to demonstrate that SLC25A39 is a primary mitochondrial transporter for GSH, providing new insights into the mechanisms underlying mitochondrial oxidative stress and metabolic regulation.