Summary:
- This article, published in *Nature Structural & Molecular Biology*, details the structural basis of how the human mitochondrial calcium uniporter (MCU) complex is regulated.
- The research utilizes cryo-electron microscopy to resolve the architecture of the MCU-EMRE-MICU1-MICU2 assembly, providing critical insights into the molecular mechanisms governing mitochondrial calcium uptake and cellular metabolic homeostasis.