Summary:
- This article provides a comprehensive review of the current landscape of polygenic risk scores (PRS), detailing their predictive utility in clinical medicine for complex diseases.
- The authors critically evaluate the methodological challenges in developing these scores, emphasizing the necessity of improving ancestral diversity in genomic datasets to ensure equitable clinical application.
- The paper outlines a strategic framework for the translation of genomic risk assessment into routine healthcare practices, while addressing the ethical and logistical hurdles of implementation.