Summary:
- Researchers have discovered a new potential cause of Alzheimer's disease - the buildup of a specific protein called TDP-43 in the brain.
- TDP-43 is normally found in the nucleus of cells, but in Alzheimer's patients, it is found in the cytoplasm, where it can disrupt normal cell function and lead to neurodegeneration.
- This finding provides a new target for potential Alzheimer's treatments, as researchers can now focus on ways to prevent the mislocalization and buildup of TDP-43 in the brain.