Only a few of the embryos derived from all-male cells went on to develop into healthy mouse pups. Embryos with DNA from three people develop normally in first safety study It will also be interesting to look at whether the ‘epigenetic’ chemical modifications to DNA that can influence gene activity are preserved properly in the eggs derived from male cells, says Fan Guo, a reproductive epigeneticist at the Chinese Academy of Sciences Institute of Zoology in Beijing, who calls Hayashi’s results “illuminating”. Fumarate induces vesicular release of mtDNA to drive innate immunityMitochondrial molecule controls inflammationMacrophage fumarate hydratase restrains mtRNA-mediated interferon productionMRC National Institute for Medical ResearchPalacky University (PU)Palacky University (PU)Palacky University (PU)Related Articles