February 17, 2023 Nanoparticle-based targeted drug delivery system for treatment of obesity and atherosclerosisNature Communications. Mechanistically, the study uncovered that adipose-targeted TH therapy can convert "bad" white fat to "good" brown fat, which can burn calories by creating heat, whereas systemic TH therapy is unable to induce "browning" of white fat due to its suppression of sympathetic nerves. Furthermore, the research team made an unexpected finding that adipose-targeted delivery of TH effectively alleviates hypercholesterolemia and atherosclerosis, major causes of coronary heart disease and ischemic stroke