New software accurately infers continental ancestry from tumor DNA and RNA

TL;DR

For Cold Spring Harbor Laboratory (CSHL) Research Professor Alexander Krasnitz, the answers may lie deep within vast databases and hospital archives containing hundreds of thousands of tumor samples.Krasnitz and CSHL Postdoctoral Fellow Pascal Belleau are working to reveal the genealogical connections between cancer and race or ethnicity.Professor Alexander Krasnitz, CSHLKrasnitz's team trained their software tools using hybrid DNA profiles.They hope to further refine their software to infer ancestry of not only whole genomes but every individual sequence therein."If we can identify more localized ancestries that are susceptible to different cancers or other aggressive diseases, it could help us pinpoint the specific part of the genome responsible and target it for treatment," Belleau says."

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