World-first: Experimental CRISPR technology removes detectable cancer cells in 13-year-oldA groundbreaking treatment has cleared a teenage girl's incurable cancer.The result needs to be monitored and confirmed over the next few monthsAlyssa was diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) in 2021 and had already received chemotherapy, a bone marrow transplant, and other therapies for her cancer."This is quite remarkable, although it is still a preliminary result, which needs to be monitored and confirmed over the next few months," said Dr. Robert Chiesa, Consultant in Bone Marrow Transplant and CAR T-cell therapy at GOSH.Therefore, the teams involved in the process used base-editing, a technique that was invented only six years ago, to create a new type of CAR T-cell therapy to attack cancerous T-cells."The doctors have said the first six months are the most important, and we don't want to get too cavalier, but we kept thinking 'If they can just get rid of it, just once, she'll be ok.' And maybe we'll be right," she said."