Researchers examined associations between metabolites and a plant-based diet pattern previously linked to reduced stroke risk in REGARDS.Secondary analyses included three additional stroke-associated diet patterns: a Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Southern diet.All of these metabolites were associated with both additional diet patterns and altered stroke risk.Mediation analyses identified guanosine (32.6% mediation, p=1.51×10-3 ), gluconic acid (35.7%, p=2.28×10-3 ), and C7 carnitine (26.2%, p=1.88×10-2 ) as mediators linking a plant-based diet to reduced stroke risk.AbstractObjective: While dietary intake is linked to stroke risk, surrogate markers that could inform personalized dietary interventions are lacking."